Index: wp-includes/functions.wp-scripts.php
===================================================================
--- wp-includes/functions.wp-scripts.php	(revision 19597)
+++ wp-includes/functions.wp-scripts.php	(working copy)
@@ -110,6 +110,10 @@
 				'<code>wp_enqueue_scripts</code>', '<code>admin_enqueue_scripts</code>', '<code>init</code>' ), '3.3' );
 		$wp_scripts = new WP_Scripts();
 	}
+	if( is_admin() && in_array( $handle, array( 'jquery' ) ) ) {
+		_doing_it_wrong( __FUNCTION__, sprintf( __( 'Please do not deregister %1$s in the admin interface, it is likely to break things.' ),
+			'<code>'.$handle.'</code>' ), null );
+	}
 
 	$wp_scripts->remove( $handle );
 }