Index: wp-admin/edit-comments.php
===================================================================
--- wp-admin/edit-comments.php	(revision 22225)
+++ wp-admin/edit-comments.php	(working copy)
@@ -102,7 +102,7 @@
 $wp_list_table->prepare_items();
 
 wp_enqueue_script('admin-comments');
-enqueue_comment_hotkeys_js();
+wp_enqueue_script('jquery-table-hotkeys');
 
 if ( $post_id )
 	$title = sprintf(__('Comments on “%s”'), wp_html_excerpt(_draft_or_post_title($post_id), 50));
Index: wp-admin/includes/screen.php
===================================================================
--- wp-admin/includes/screen.php	(revision 22225)
+++ wp-admin/includes/screen.php	(working copy)
@@ -904,6 +904,9 @@
 			case 'widgets':
 				$this->_screen_settings = '<p><a id="access-on" href="widgets.php?widgets-access=on">' . __('Enable accessibility mode') . '</a><a id="access-off" href="widgets.php?widgets-access=off">' . __('Disable accessibility mode') . "</a></p>\n";
 				break;
+			case 'edit-comments' :
+				$this->_screen_settings = '<div><label for="comment_shortcuts"><input id="comment_shortcuts" name="comment_shortcuts" type="checkbox" checked="checked" /> ' . __( 'Use comment shortcuts' ) . "</label></div>\n" . $this->_screen_settings;
+				break;
 		}
 
 		if ( $this->_screen_settings || $this->_options )
Index: wp-admin/js/edit-comments.js
===================================================================
--- wp-admin/js/edit-comments.js	(revision 22225)
+++ wp-admin/js/edit-comments.js	(working copy)
@@ -555,7 +555,8 @@
 };
 
 $(document).ready(function(){
-	var make_hotkeys_redirect, edit_comment, toggle_all, make_bulk;
+	var make_hotkeys_redirect, edit_comment, toggle_all, make_bulk,
+		shortcuts = $('#comment_shortcuts'), keys = false;
 
 	setCommentsList();
 	commentReply.init();
@@ -591,15 +592,39 @@
 			}
 		};
 
-		$.table_hotkeys(
-			$('table.widefat'),
-			['a', 'u', 's', 'd', 'r', 'q', 'z', ['e', edit_comment], ['shift+x', toggle_all],
-			['shift+a', make_bulk('approve')], ['shift+s', make_bulk('spam')],
-			['shift+d', make_bulk('delete')], ['shift+t', make_bulk('trash')],
-			['shift+z', make_bulk('untrash')], ['shift+u', make_bulk('unapprove')]],
-			{ highlight_first: adminCommentsL10n.hotkeys_highlight_first, highlight_last: adminCommentsL10n.hotkeys_highlight_last,
-			prev_page_link_cb: make_hotkeys_redirect('prev'), next_page_link_cb: make_hotkeys_redirect('next') }
-		);
+		function add_hotkeys() {
+			if ( keys ) return;
+			keys = true;
+			$.table_hotkeys(
+				$('table.widefat'),
+				['a', 'u', 's', 'd', 'r', 'q', 'z', ['e', edit_comment], ['shift+x', toggle_all],
+				['shift+a', make_bulk('approve')], ['shift+s', make_bulk('spam')],
+				['shift+d', make_bulk('delete')], ['shift+t', make_bulk('trash')],
+				['shift+z', make_bulk('untrash')], ['shift+u', make_bulk('unapprove')]],
+				{ highlight_first: adminCommentsL10n.hotkeys_highlight_first, highlight_last: adminCommentsL10n.hotkeys_highlight_last,
+				prev_page_link_cb: make_hotkeys_redirect('prev'), next_page_link_cb: make_hotkeys_redirect('next') }
+			);
+		}
+
+		function remove_hotkeys() {
+			var r = $.hotkeys.remove;
+			if ( ! keys ) return;
+			$('.vim-current').removeClass('vim-current');
+			keys = false;
+			r('a'), r('u'), r('s'), r('d'), r('r'), r('q'), r('z'), r('e'), r('shift+x'),
+			r('shift+a'), r('shift+s'), r('shift+d'), r('shift+t'), r('shift+z'), r('shift+u');
+		}
+
+		shortcuts.change( function(){
+			if ( $(this).prop('checked') )
+				add_hotkeys();
+			else
+				remove_hotkeys();
+		});
+		if ( shortcuts.prop('checked') ) {
+			add_hotkeys();
+			keys = true;
+		}
 	}
 });