Index: wp-includes/general-template.php
===================================================================
--- wp-includes/general-template.php	(revision 19631)
+++ wp-includes/general-template.php	(working copy)
@@ -593,7 +593,7 @@
 	}
 
 	$prefix = '';
-	if ( !empty($title) )
+	if ( !empty( $title ) && !empty( $sep ) )
 		$prefix = " $sep ";
 
  	// Determines position of the separator and direction of the breadcrumb
