Index: inline-edit-post.js
===================================================================
--- inline-edit-post.js	(revision 25918)
+++ inline-edit-post.js	(working copy)
@@ -223,6 +223,10 @@
 		if ( typeof(id) == 'object' )
 			id = this.getId(id);
 
+		if ( $("#edit-"+id+" a.save").hasClass("button-primary-disabled") )
+			return false;
+
+		$("#edit-"+id+" a.save").addClass("button-primary-disabled");
 		$('table.widefat .spinner').show();
 
 		params = {
Index: inline-edit-tax.js
===================================================================
--- inline-edit-tax.js	(revision 25918)
+++ inline-edit-tax.js	(working copy)
@@ -60,6 +60,10 @@
 		if( typeof(id) == 'object' )
 			id = this.getId(id);
 
+		if ( $("#edit-"+id+" a.save").hasClass("button-primary-disabled") )
+			return false;
+
+		$("#edit-"+id+" a.save").addClass("button-primary-disabled");
 		$('table.widefat .spinner').show();
 
 		params = {