diff --git src/wp-includes/plugin.php src/wp-includes/plugin.php
index c83ebdb81f..44520a5612 100644
--- src/wp-includes/plugin.php
+++ src/wp-includes/plugin.php
@@ -844,10 +844,12 @@ function register_uninstall_hook( $file, $callback ) {
 	 * cases. Emphasis should be put on using the 'uninstall.php' way of
 	 * uninstalling the plugin.
 	 */
-	$uninstallable_plugins                             = (array) get_option( 'uninstall_plugins' );
-	$uninstallable_plugins[ plugin_basename( $file ) ] = $callback;
-
-	update_option( 'uninstall_plugins', $uninstallable_plugins );
+	$uninstallable_plugins = (array) get_option( 'uninstall_plugins' );
+	$plugin_basename       = plugin_basename( $file );
+	if ( ! isset( $uninstallable_plugins[ $plugin_basename ] ) || $uninstallable_plugins[ $plugin_basename ] !== $callback ) {
+		$uninstallable_plugins[ $plugin_basename ] = $callback;
+		update_option( 'uninstall_plugins', $uninstallable_plugins );
+	}
 }
 
 /**