Index: src/wp-admin/js/color-picker.js
===================================================================
--- src/wp-admin/js/color-picker.js	(revision 33022)
+++ src/wp-admin/js/color-picker.js	(working copy)
@@ -128,7 +128,11 @@
 			$( 'body' ).trigger( 'click.wpcolorpicker' ).on( 'click.wpcolorpicker', this.close );
 		},
 		close: function() {
-			this.element.hide().iris( 'toggle' );
+			this.element.hide();
+			// if iris hasn't already been destroyed
+			if ( this.element.iris( 'instance' ) ) {
+				this.element.iris( 'toggle' );
+			}
 			this.button.addClass( 'hidden' );
 			this.toggler.removeClass( 'wp-picker-open' );
 			$( 'body' ).off( 'click.wpcolorpicker', this.close );