Index: src/wp-admin/user/admin.php
--- src/wp-admin/user/admin.php
+++ src/wp-admin/user/admin.php
@@ -11,15 +11,16 @@

 require_once dirname( __DIR__ ) . '/admin.php';

-if ( ! is_multisite() ) {
-	wp_redirect( admin_url() );
-	exit;
-}
+if ( is_multisite() ) {
+	$redirect_user_admin_request = ( 0 !== strcasecmp( $current_blog->domain, $current_site->domain ) || 0 !== strcasecmp( $current_blog->path, $current_site->path ) );
+	$redirect_to_url             = user_admin_url();
+} else {
+	$redirect_user_admin_request = true;
+	$redirect_to_url             = admin_url( 'profile.php' );
+ }

-$redirect_user_admin_request = ( 0 !== strcasecmp( $current_blog->domain, $current_site->domain ) || 0 !== strcasecmp( $current_blog->path, $current_site->path ) );
-
 /**
- * Filters whether to redirect the request to the User Admin in Multisite.
+ * Filters whether to redirect the request to the User Admin.
  *
  * @since 3.2.0
  *
@@ -28,8 +29,8 @@
 $redirect_user_admin_request = apply_filters( 'redirect_user_admin_request', $redirect_user_admin_request );

 if ( $redirect_user_admin_request ) {
-	wp_redirect( user_admin_url() );
+	wp_redirect( $redirect_to_url );
 	exit;
 }

-unset( $redirect_user_admin_request );
+unset( $redirect_user_admin_request, $redirect_to_url );