diff --git src/wp-includes/l10n.php src/wp-includes/l10n.php
index 915fa72701..39aa6d498e 100644
--- src/wp-includes/l10n.php
+++ src/wp-includes/l10n.php
@@ -1364,6 +1364,7 @@ function wp_get_pomo_file_data( $po_file ) {
  * @since 4.0.0
  * @since 4.3.0 Introduced the `echo` argument.
  * @since 4.7.0 Introduced the `show_option_site_default` argument.
+ * @since 5.1.0 Introduced the `show_option_en_us` argument.
  *
  * @see get_available_languages()
  * @see wp_get_available_translations()
@@ -1382,6 +1383,7 @@ function wp_get_pomo_file_data( $po_file ) {
  *                                                  boolean equivalents. Default 1.
  *     @type bool     $show_available_translations  Whether to show available translations. Default true.
  *     @type bool     $show_option_site_default     Whether to show an option to fall back to the site's locale. Default false.
+ *     @type bool     $show_option_en_us            Whether to show an option for English (United States). Default true.
  * }
  * @return string HTML content
  */
@@ -1398,6 +1400,7 @@ function wp_dropdown_languages( $args = array() ) {
 			'echo'                        => 1,
 			'show_available_translations' => true,
 			'show_option_site_default'    => false,
+			'show_option_en_us'           => true,
 		)
 	);
 
@@ -1461,11 +1464,12 @@ function wp_dropdown_languages( $args = array() ) {
 		);
 	}
 
-	// Always show English.
-	$structure[] = sprintf(
-		'<option value="" lang="en" data-installed="1"%s>English (United States)</option>',
-		selected( '', $parsed_args['selected'], false )
-	);
+	if ( $parsed_args['show_option_en_us'] ) {
+		$structure[] = sprintf(
+			'<option value="" lang="en" data-installed="1"%s>English (United States)</option>',
+			selected( '', $parsed_args['selected'], false )
+		);
+	}
 
 	// List installed languages.
 	foreach ( $languages as $language ) {
diff --git tests/phpunit/tests/l10n.php tests/phpunit/tests/l10n.php
index 5173621d2c..930108228a 100644
--- tests/phpunit/tests/l10n.php
+++ tests/phpunit/tests/l10n.php
@@ -124,6 +124,24 @@ class Tests_L10n extends WP_UnitTestCase {
 		$this->assertContains( '<option value="ja_JP" lang="ja">日本語</option>', $actual );
 	}
 
+	/**
+	 * @ticket 44494
+	 */
+	function test_wp_dropdown_languages_exclude_en_us() {
+		$args   = array(
+			'id'                       => 'foo',
+			'name'                     => 'bar',
+			'languages'                => array( 'de_DE' ),
+			'translations'             => $this->wp_dropdown_languages_filter(),
+			'selected'                 => 'de_DE',
+			'echo'                     => false,
+			'show_option_en_us'        => false,
+		);
+		$actual = wp_dropdown_languages( $args );
+
+		$this->assertNotContains( '<option value="" lang="en" data-installed="1">English (United States)</option>', $actual );
+	}
+
 	/**
 	 * @ticket 38632
 	 */