Index: src/wp-includes/class-wp-image-editor-imagick.php
===================================================================
--- src/wp-includes/class-wp-image-editor-imagick.php	(revision 46823)
+++ src/wp-includes/class-wp-image-editor-imagick.php	(working copy)
@@ -140,16 +140,17 @@
 		try {
 			$this->image    = new Imagick();
 			$file_extension = strtolower( pathinfo( $this->file, PATHINFO_EXTENSION ) );
-			$filename       = $this->file;
 
 			if ( 'pdf' === $file_extension ) {
-				$filename = $this->pdf_setup();
+				$pdf_loaded = $this->pdf_load_source();
+
+				if ( is_wp_error( $pdf_loaded ) ) {
+					return $pdf_loaded;
+				}
+			} else {
+				$this->image->readImage( $this->file );
 			}
 
-			// Reading image after Imagick instantiation because `setResolution`
-			// only applies correctly before the image is read.
-			$this->image->readImage( $filename );
-
 			if ( ! $this->image->valid() ) {
 				return new WP_Error( 'invalid_image', __( 'File is not an image.' ), $this->file );
 			}
@@ -165,6 +166,7 @@
 		}
 
 		$updated_size = $this->update_size();
+
 		if ( is_wp_error( $updated_size ) ) {
 			return $updated_size;
 		}
@@ -794,15 +796,46 @@
 			// We want the thumbnail to be readable, so increase the rendering DPI.
 			$this->image->setResolution( 128, 128 );
 
+			// Only load the first page.
+			return $this->file . '[0]';
+		} catch ( Exception $e ) {
+			return new WP_Error( 'pdf_setup_failed', $e->getMessage(), $this->file );
+		}
+	}
+
+	/**
+	 * Load the image produced by Ghostscript.
+	 *
+	 * Includes a workaround for a bug in Ghostscript 8.7 that may prevent processing of some PDF files
+	 * when `use-cropbox` is set.
+	 *
+	 * @since 5.3.1
+	 *
+	 * @return true|WP_error
+	 */
+	protected function pdf_load_source() {
+		$filename = $this->pdf_setup();
+
+		if ( is_wp_error( $filename ) ) {
+			return $filename;
+		}
+
+		try {
 			// When generating thumbnails from cropped PDF pages, Imagemagick uses the uncropped
 			// area (resulting in unnecessary whitespace) unless the following option is set.
 			$this->image->setOption( 'pdf:use-cropbox', true );
 
-			// Only load the first page.
-			return $this->file . '[0]';
+			// Reading image after Imagick instantiation because `setResolution`
+			// only applies correctly before the image is read.
+			$this->image->readImage( $filename );
 		} catch ( Exception $e ) {
-			return new WP_Error( 'pdf_setup_failed', $e->getMessage(), $this->file );
+			// Attempt to run `gs` without the `use-cropbox` option. See #48853.
+			$this->image->setOption( 'pdf:use-cropbox', false );
+
+			$this->image->readImage( $filename );
 		}
+
+		return true;
 	}
 
 }